Studi Literatur Pengaruh Paparan Pestisida terhadap Fungsi Paru
DOI:
https://doi.org/10.58192/populer.v5i2.4996Keywords:
Farmers, Lung Function, Occupational Health, Personal Protective Equipment, Pesticide ExposureAbstract
Pesticide exposure is a major occupational health issue in the agricultural sector, particularly among farmers directly involved in pesticide mixing and spraying activities. Exposure occurs through multiple routes, primarily inhalation and dermal contact, and may adversely affect lung function. This study aims to review the determinants of pesticide exposure associated with impaired lung function among farmers using a narrative review approach. Literature searches were conducted across several scientific databases, including Google Scholar, PubMed, NCBI, ScienceDirect, and Elsevier, using publications in both English and Indonesian. The findings indicate that pesticide type and toxicity level, duration of employment, frequency and duration of spraying, and poor compliance with personal protective equipment use are key determinants associated with reduced lung function. The underlying pathophysiological mechanisms include airway inflammation, oxidative stress, alveolar damage, and reduced pulmonary diffusion capacity. Long-term exposure has been linked to an increased risk of chronic respiratory diseases, including chronic obstructive pulmonary disease. Preventive strategies such as education on safe pesticide use, improved compliance with personal protective equipment, and regular pulmonary function monitoring are essential to reduce health risks among farmers.
References
Angaye, T., & Lelei, K. (2022). The toxicity of synthetic pesticides in the Niger Delta Region: A review. Archives of Ecotoxicology, 4(4), 105–108. https://doi.org/10.36547/ae.2022.4.4.105-108
Assis, M., Barcella, R., Padilha, J., Pohl, H., & Krug, S. (2020). Health problems in agricultural workers occupationally exposed to pesticides. Revista Brasileira de Medicina do Trabalho, 18(3), 352–363. https://doi.org/10.47626/1679-4435-2020-532
Benka-Coker, W., Hoskovec, L., Severson, R., Balmes, J., Wilson, A., & Magzamen, S. (2020). The joint effect of ambient air pollution and agricultural pesticide exposures on lung function among children with asthma. Environmental Research, 190, 109903. https://doi.org/10.1016/j.envres.2020.109903
Boonkhao, L., Baukeaw, W., Saenrueang, T., & Rattanachaikunsopon, P. (2023). Factors influencing the level of health risks from pesticide exposure among vegetable farmers. SEHS, 17, 23050006. https://doi.org/10.69598/sehs.17.23050006
Bunsri, S., Muenchamnan, N., Naksen, W., & Ong-Artborirak, P. (2023). The hematological and biochemical effects from pesticide exposure on Thai vegetable farmers. Toxics, 11(8), 707. https://doi.org/10.3390/toxics11080707
Buralli, R., Dultra, A., & Ribeiro, H. (2020). Respiratory and allergic effects in children exposed to pesticides: A systematic review. International Journal of Environmental Research and Public Health, 17(8), 2740. https://doi.org/10.3390/ijerph17082740
Burns, C., & Juberg, D. (2021). Cancer and occupational exposure to pesticides: An umbrella review. International Archives of Occupational and Environmental Health, 94(5), 945–957. https://doi.org/10.1007/s00420-020-01638-y
Chekol, G. (2024). Understanding the factors behind non-adherence to pesticide safety guidelines among smallholder farmers in Fogera and Mecha Districts, Northwestern Ethiopia. https://doi.org/10.21203/rs.3.rs-4763735/v1
Dhansoia, V., Majumdar, V., Manjunath, N., Gaharwar, U., & Singh, D. (2022). Breathing-focused yoga intervention on respiratory decline in chronically pesticide-exposed farmers: A randomized controlled trial. Frontiers in Medicine, 9. https://doi.org/10.3389/fmed.2022.807612
Hamzah, N., Zahari, N., Yhaya, M., Anua, S., Samad, N., Mamat, M., et al. (2023). Occupational pesticide exposure and respiratory effects among mosquito control workers in Kota Bharu and Bachok, Kelantan. Journal of Energy and Safety Technology, 5(2), 39–51. https://doi.org/10.11113/jest.v5n2.117
Kangkhetkron, T., & Juntarawijit, C. (2021). Pesticide exposure and lung cancer risk: A case-control study in Nakhon Sawan, Thailand. F1000Research, 9, 492. https://doi.org/10.12688/f1000research.24114.4
Keleb, A., Daba, C., Asmare, L., Bayou, F., Arefaynie, M., Mohammed, A., et al. (2024). The association between children's exposure to pesticides and asthma, wheezing, and lower respiratory tract infections: A systematic review and meta-analysis. Frontiers in Public Health, 12. https://doi.org/10.3389/fpubh.2024.1402908
Lee, S., Han, J., Woo, S., & Lee, S. (2022). Occupational factors affecting the decline in pulmonary function among male farmers using occupational pesticide in Gyeonggi-do, South Korea. Annals of Occupational and Environmental Medicine, 34(1), e42. https://doi.org/10.35371/aoem.2022.34.e42
Liem, J., Mansyur, M., Soemarko, D., Kekalih, A., Subekti, I., Suyatna, F., et al. (2021). Cumulative exposure characteristics of vegetable farmers exposed to chlorpyrifos in Central Java, Indonesia: A cross-sectional study. BMC Public Health, 21(1). https://doi.org/10.1186/s12889-021-11161-5
Mahawati, E. (2023). Effect of safety and hygiene practices on lung function among Indonesian farmers exposed to pesticides. South Eastern European Journal of Public Health. https://doi.org/10.56801/seejph.vi.262
Manfo, F. P. T., Mboe, S. A., Nantia, E. A., Ferdinand, N. N., Telefo, P. B., Moundipa, P. F., et al. (2020). Evaluation of the effects of agro pesticides use on liver and kidney function in farmers from Buea, Cameroon. Journal of Toxicology, 2020, 2305764. https://doi.org/10.1155/2020/2305764
Manfo, F. P. T., Nimako, C. A., Nantia, E. A., Suh, C. E., Chenwi, S. T., Cho-Ngwa, F., et al. (2024). Exposure of male farmers and nonfarmers to neonicotinoid pesticides in the South-West and Littoral Regions of Cameroon: A comparative study. Environmental Toxicology and Chemistry, 43(5), 952–964. https://doi.org/10.1002/etc.5842
Manfo, F. P. T., Suh, C. E., Nantia, E. A., Moundipa, P. F., & Cho-Ngwa, F. (2021). Occupational use of agrochemicals results in inhibited cholinesterase activity and altered reproductive hormone levels in male farmers from Buea, Cameroon. Toxicology Research, 10(2), 232–248. https://doi.org/10.1093/toxres/tfaa113
Marete, G. M., Lalah, J. O., Mputhia, J., & Wekesa, V. W. (2021). Pesticide usage practices as sources of occupational exposure and health impacts on horticultural farmers in Meru County, Kenya. Heliyon, 7(2), e06118. https://doi.org/10.1016/j.heliyon.2021.e06118
Mawardi, S., Dekasari, V., Handayani, I., Kurniyawan, E., Nur, K., Kurniawan, D., et al. (2025). Causative factors of respiratory tract disorders among agricultural workers. Health and Technology Journal, 3(3), 365–378. https://doi.org/10.53713/htechj.v3i3.327
Mehta, R., Sreenivasa, M., Mathew, M., Girard, A., Taneja, S., Ranjan, S., et al. (2020). A mixed-methods study of pesticide exposures in breastmilk and community and lactating women's perspectives from Haryana, India. BMC Public Health, 20(1). https://doi.org/10.1186/s12889-020-09966-x
Nambunmee, K., Kawiya, T., Neitzel, R. L., & Seeprasert, P. (2021). Pesticide spraying and reduced cholinesterase activity among hill tribe farmers in Thailand. Journal of Health and Pollution, 11(31). https://doi.org/10.5696/2156-9614-11.31.210908
Nurcandra, F., Mahkota, R., & Wahyono, T. Y. M. (2020). Adverse effect of aerosol pesticide on lung dysfunction among paddy farmers in Purworejo, Central Java, Indonesia. Kesmas: National Public Health Journal, 15(2). https://doi.org/10.21109/kesmas.v15i2.2703
Olirk, B., Mamuya, S., Mosha, I., Moen, B., & Ngowi, A. (2025). Occupational pesticide exposure risks and gendered experiences among women in horticultural farms in Northern Tanzania. International Journal of Environmental Research and Public Health, 22(10), 1529. https://doi.org/10.3390/ijerph22101529
Onyando, Z., Omukunda, E., Okoth, P., Khatiebi, S., Omwoma, S., Otieno, P., et al. (2023). Screening and prioritization of pesticide application for potential human health and environmental risks in large-scale farms in Western Kenya. Agriculture, 13(6), 1178. https://doi.org/10.3390/agriculture13061178
Pedroso, T., Benvindo-Souza, M., Nascimento, F., Woch, J., Reis, F., & Silva, D. (2021). Cancer and occupational exposure to pesticides: A bibliometric study of the past 10 years. Environmental Science and Pollution Research, 29(12), 17464–17475. https://doi.org/10.1007/s11356-021-17031-2
Ramírez-Santana, M., Zúñiga-Venegas, L., Corral, S., Roeleveld, N., Groenewoud, H., Velden, K., et al. (2020). Association between cholinesterase inhibition and cognitive impairment: A basis for prevention policies of environmental pollution by organophosphate and carbamate pesticides in Chile. Environmental Research, 186, 109539. https://doi.org/10.1016/j.envres.2020.109539
Rasiska, S., Sudarjat, S., Dono, D., Suganda, T., & Setiawan, I. (2025). Evaluation behavior of highland vegetable farmers on West Bandung Regency to use good pesticide practices. Cropsaver: Journal of Plant Protection, 8(1), 35–46. https://doi.org/10.24198/cropsaver.v8i1.62005
Ratanachina, J., Amaral, A. F. S., De Matteis, S., Cullinan, P., & Burney, P. (2021). Farming, pesticide exposure and respiratory health: A cross-sectional study in Thailand. Occupational and Environmental Medicine, 79(1), 38–45. https://doi.org/10.1136/oemed-2020-107325
Ratanachina, J., Amaral, A. F. S., De Matteis, S., Lawin, H., Mortimer, K., Obaseki, D., et al. (2022). Association of respiratory symptoms and lung function with occupation in the multinational Burden of Obstructive Lung Disease (BOLD) study. European Respiratory Journal, 61(1), 2200469. https://doi.org/10.1183/13993003.00469-2022
Rath, I., Mishra, J., Verma, K., Pradhan, A., & Pani, P. (2024). Assessing pulmonary function in workers exposed to rice threshing processes. Journal of Ecophysiology and Occupational Health, 281–286. https://doi.org/10.18311/jeoh/2024/36482
Salami, I., & Oginawati, K. (2024). Pesticide residue exposure effect on health, growth, and development among children from agricultural area. E3S Web of Conferences, 485, 07009. https://doi.org/10.1051/e3sconf/202448507009
Salehipour, S., Saedi, A., Assadollahi, Z., Lotfi, M., Rahmani, M., Nosratabadi, F., et al. (2024). The impact of pesticides exposure on thyroid function in Rafsanjan farmers in 2023–2024: A case-control study. Journal of Environmental Health and Sustainable Development. https://doi.org/10.18502/jehsd.v9i4.17392
Sapbamrer, R., Sittitoon, N., Thongtip, S., Chaipin, E., Sutalangka, C., Chaiut, W., et al. (2024). Acute health symptoms related to perception and practice of pesticides use among farmers from all regions of Thailand. Frontiers in Public Health, 11. https://doi.org/10.3389/fpubh.2023.1296082
Shakya, A., & Acharya, N. (2023). Factors affecting the knowledge of vegetable farmers of Chitwan and Makwanpur district over pesticide use. Archives of Agriculture and Environmental Science, 8(2), 221–227. https://doi.org/10.26832/24566632.2023.0802019
Shentema, M., Kumie, A., Bråtveit, M., Deressa, W., Ngowi, A., & Moen, B. (2020). Pesticide use and serum acetylcholinesterase levels among flower farm workers in Ethiopia: A cross-sectional study. International Journal of Environmental Research and Public Health, 17(3), 964. https://doi.org/10.3390/ijerph17030964
Shi, L., Yu, G., Zhao, L., Wen, Z., Li, Y., Kan, B., et al. (2022). Methemoglobinemia and delayed encephalopathy after 5-bromo-2-nitropyridine poisoning: A rare case report. Frontiers in Public Health, 10. https://doi.org/10.3389/fpubh.2022.942003
Sitompul, D., Lumbantobing, P., Manik, S., & Harefa, M. (2024). Optimasi penggunaan bio-pestisida sebagai pengganti pestisida kimia pada pertanian di Kec. Percut Sei Tuan, Kab. Deli Serdang. El-Mujtama: Jurnal Pengabdian Masyarakat, 4(2). https://doi.org/10.47467/elmujtama.v4i2.1281
Țărmure, S., Alexescu, T., Orășan, O., Negrean, V., Sitar-Tăut, A., Coste, S., et al. (2020). Influence of pesticides on respiratory pathology: A literature review. Annals of Agricultural and Environmental Medicine, 27(2), 194–200. https://doi.org/10.26444/aaem/121899
Tham-Agyekum, E., Ankuyi, F., Jones, E., Tierku, A., Sarfo, D., Bakang, J., et al. (2024). Cocoa farmers and agrochemical safety compliance: Empirical insights from Ghana. Pelita Perkebunan (A Coffee and Cocoa Research Journal), 40(1), 91–104. https://doi.org/10.22302/iccri.jur.pelitaperkebunan.v40i1.589
Vorselaars, A. D. M., Berg, P. van den, & Drent, M. (2021). Severe pulmonary toxicity associated with inhalation of pyrethroid-based domestic insecticides (Bop/Sapolio): A case series and literature review. Current Opinion in Pulmonary Medicine, 27(4), 271–277. https://doi.org/10.1097/MCP.0000000000000779
Wadani, Z., Azam, I., Irfan, M., & Fatmi, Z. (2021). Pesticides use and impaired lung function among male agricultural farmers in rural Sindh, Pakistan. Asia Pacific Journal of Public Health, 34(2–3), 230–235. https://doi.org/10.1177/10105395211065647
Woldeamanuel, G. G., Mingude, A. B., Yitbarek, G. Y., & Taderegew, M. M. (2020). Chronic respiratory symptoms and pulmonary function status in Ethiopian agricultural workers: A comparative study. BMC Pulmonary Medicine, 20(1). https://doi.org/10.1186/s12890-020-1120-3
Xu, R., Rahmandad, H., Gupta, M., DiGennaro, C., Ghaffarzadegan, N., Amini, H., et al. (2021). Weather, air pollution, and SARS-CoV-2 transmission: A global analysis. The Lancet Planetary Health, 5(10), e671–e680. https://doi.org/10.1016/S2542-5196(21)00202-3
Zaw, T., Phyu, M., & Kyaw, S. (2020). Erythrocyte acetylcholinesterase enzyme activity, serum interleukin-6 level and respiratory function of Myanmar agricultural workers exposed to organophosphate pesticides. International Journal of Clinical and Experimental Physiology, 7(3), 107–111. https://doi.org/10.5530/ijcep.2020.7.3.26
Zheng, R., García-González, J., Rey, R., López-Villén, A., García-Álvarez, R., Fadul-Calderón, R., et al. (2023). Occupational exposure to pesticides as a risk factor for sleep disorders. International Journal of Environmental Research and Public Health, 20(4), 3149. https://doi.org/10.3390/ijerph20043149
Zúñiga-Venegas, L., & Pancetti, F. (2022). DNA damage in a Chilean population exposed to pesticides and its association with PON1 (Q192R and L55M) susceptibility biomarker. Environmental and Molecular Mutagenesis, 63(4), 215–226. https://doi.org/10.1002/em.22485
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Populer: Jurnal Penelitian Mahasiswa

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.









